Vancomycin minimum inhibitory concentrations and lethality in Staphylococcus aureus bacteremia

Antibiotic choice may not explain poorer outcomes in patients with Staphylococcus aureus bacteremia and high vancomycin minimum inhibitory concentrations.

BACKGROUND There are concerns about reduced efficacy of vancomycin in patients with Staphylococcus aureus bacteremia (SAB), especially when the minimum inhibitory concentration (MIC) nears the upper limit of the susceptible range. METHODS We examined the relationship between antibiotic treatment, 30-day mortality, and microbiologic parameters in a large Australasian cohort of patients with SA...

Role of high vancomycin minimum inhibitory concentration in the outcome of methicillin-susceptible Staphylococcus aureus bacteremia.

Correspondence Role of High Vancomycin Minimum Inhibitory Concentration in the Outcome of Methicillin-Susceptible Staphylococcus aureus Bacteremia To the Editor—We read with great interest the article by Holmes et al [1] and the editorial commentary published in the same issue [2] regarding the novel topic of the potential role of high minimum inhibitory concentration (MIC) levels of vancomycin...

Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia.

BACKGROUND Vancomycin treatment failure in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is not uncommon, even when MRSA is susceptible to vancomycin. The aim of our study was to evaluate whether vancomycin minimum inhibitory concentration has any influence on the mortality associated with MRSA bacteremia. METHODS A total of 414 episodes of MRSA bacteremia were prospectively f...

Vancomycin minimum inhibitory concentrations and outcome in patients with severe Staphylococcus aureus infection.

To the Editor—As Holland and Fowler point out in their excellent commentary [1], there are many unresolved issues in the measurement and clinical interpretation of vancomycin minimum inhibitory concentrations (MICs). There is, however, one major omission from their otherwise comprehensive review of published, peer-reviewed outcome studies versus MIC in serious methicillin-resistant Staphylococc...

Vancomycin minimum inhibitory concentrations using different susceptibility methods in Staphylococcus aureus isolates.